Réaction #165930

Équation de réaction

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

Sodium sulphite

→

Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

Rendement 91.4%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   AutreReaction mass
2. 2
   AutreOrganic and aqueous layer separated dichloromethane layer
3. 3
   Lavagewas washed with water (2×200 ml)
4. 4
   ConcentrationDichloromethane layer was then concentrated to residue

Mode opératoire

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (100 g) dissolved in dichloromethane (500 ml). Sodium sulphite solution (15%, 1000 ml) was added to it. Reaction mass was stirred for 8 hrs. Organic and aqueous layer separated dichloromethane layer was washed with water (2×200 ml). Dichloromethane layer was then concentrated to residue to get Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 67 g)

Source