Réaction #165751

Équation de réaction

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

Rendement 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

Rendement 70.0%

Solvants

DCM

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwere added
2. 2
   Autrethe solvent was removed in vacuo
3. 3
   Autrethe residue triturated with MeOH
4. 4
   FiltrationThe resultant filtrate was filtered off

Mode opératoire

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

Source