Réaction #165218

Équation de réaction

(4-(2-(tetrahydrofuran-2-yl)-ethyl)-phenyl)-methanol

→

title compound

Rendement 95.1%

4-(2-(Tetrahydrofuran-2-yl)-ethyl)-benzaldehyde

Rendement 95.1%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   AutreThe reaction liquid
2. 2
   Filtrationfiltered through a Celite pad
3. 3
   Lavagewashed with ethyl acetate (50 mL)
4. 4
   ConcentrationThe filtrate was concentrated under a reduced pressure

Mode opératoire

To an ethyl acetate (50 mL) solution of (4-(2-(tetrahydrofuran-2-yl)-ethyl)-phenyl)-methanol (600 mg, 2.91 mmol) described in Manufacturing Example 82-1-2 was added active manganese dioxide (10 g, 115 mmol), which was stirred for 12 hours at room temperature. The reaction liquid was suction filtered through a Celite pad, and washed with ethyl acetate (50 mL). The filtrate was concentrated under a reduced pressure to obtain the title compound (565 mg, 95%).

Source