Réaction #1637

Équation de réaction

(S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

benzyl bromide

sodium carbonate

→

title compound

(S)-N-Benzyl-1(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   FiltrationThe mixture was filtered
2. 2
   Lavagethe residue was washed with ethyl acetate
3. 3
   Lavagewashed with water and brine
4. 4
   Autredried
5. 5
   Autreevaporated
6. 6
   AutrePurification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane)

Mode opératoire

A solution of (S)-1-(4-benzyloxyphenoxy)-3-[N-2-(4-hydroxyphenyl)ethylamino]propan-2-ol (1.9 g, 4.8 mMol) and benzyl bromide (0.57 ml, 4.8 mMol) in dimethylformamide (10 ml) containing sodium carbonate (770 mg, 7.2 mMol) was stirred at room temperature for 18 hours. The mixture was filtered and the residue was washed with ethyl acetate. The filtrates were combined, washed with water and brine, dried and evaporated. Purification of the residue by flash chromatography (silica gel, 50% ethyl acetate in hexane) gave the title compound.

Source