Réaction #162201

Équation de réaction

2-Hydroxy-3-nitro-benzoic acid

HCl

→

3-amino-2-hydroxy-cyclohexanecarboxylic acid

Conditions de réaction

Traitement

1. 1
   FiltrationThe catalyst was filtered
2. 2
   Lavagewashed with hot H2O
3. 3
   AutreThe filtrate was evaporated

Mode opératoire

2-Hydroxy-3-nitro-benzoic acid (5.0 g, 27.3 mmol) was mixed with HCl (125 mL of 0.5 M, 62.5 mmol) and dioxoplatinum (1.0 g, 4.4 mmol) in a hydrogenation bottle. The mixture was placed on a Parr shaker (50 psi H2) for 24 hours. The catalyst was filtered and washed with hot H2O. The filtrate was evaporated to provide 3-amino-2-hydroxy-cyclohexanecarboxylic acid as a mixture of stereoisomers which was utilized to the next step without further purification.

Source