Réaction #1621

Équation de réaction

(R)-5-[N-(t-butyloxycarbonyl)-2-aminopropyl]-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester

diethyl ether

hydrogen chloride

→

title compound

(R)-5-(2-Aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester, hydrochloride salt

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was evaporated
2. 2
   Autrethe residue was dried

Mode opératoire

A solution of (R)-5-[N-(t-butyloxycarbonyl)-2-aminopropyl]-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester (3.0 g, 7 mMol) in ethyl acetate (40 ml) and hydrogen chloride solution in diethyl ether (1M, 56 ml, 56 mMol) was stirred at ambient temperature under an argon atmosphere for 48 hours. The solvent was evaporated and the residue was dried giving the title compound as a glass.

Source