Réaction #1617937

ord-b4b6f420b137465c865a874a1d809e54

Équation de réaction

O=C(O)c1ccc(O)cc1F
4-hydroxy-2-fluorobenzoic acid
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)Oc1ccc(C(=O)O)c(F)c1
4-acetoxy-2-fluorobenzoic acid

Réactifs

O=C(O)c1ccc(O)cc1F
4-hydroxy-2-fluorobenzoic acid
CC(=O)OC(C)=O
acetic anhydride

Réactifs

O=S(=O)(O)O
sulfuric acid

Solvants

O
water
O
water

Conditions de réaction

Température
80°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    workup.ADDITIONmixed
  2. 2
    workup.ADDITIONwere added
  3. 3
    TempératureAfter heat generation
  4. 4
    Filtrationa precipitated crystal was recovered by filtration

Mode opératoire

4.3 Grams of 4-hydroxy-2-fluorobenzoic acid and 8.4 g of acetic anhydride were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid were added. After heat generation ended, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and a precipitated crystal was recovered by filtration.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06197216B1uspto-grants-2001_03