Réaction #161766

Équation de réaction

methyl 2-chloro-6-methanesulphonylamino-isonicotinate

lithium hydroxide

hydrochloric acid

→

2-chloro-6-methanesulphonylamino-isonicotinic acid

Solvants

tetrahydrofuran

water

Conditions de réaction

Traitement

1. 1
   Autreevaporated down
2. 2
   AutreThe product was reacted without further purification

Mode opératoire

0.29 g (1.1 mmol) methyl 2-chloro-6-methanesulphonylamino-isonicotinate in 5.0 mL tetrahydrofuran and 1 mL water were mixed with 79 mg (3.3 mmol) lithium hydroxide and stirred overnight at RT. The reaction mixture was acidified with 1M aqueous hydrochloric acid and evaporated down. The product was reacted without further purification.

Source