Réaction #161722

Équation de réaction

4,5-difluoro-1,3-dihydro-indol-2-one

acetic anhydride

→

1-acetyl-4,5-difluoro-1,3-dihydro-indol-2-one

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   Lavagewashed with water
3. 3
   AutreThe product was recrystallised from a mixture of water and ethanol, suction
4. 4
   Filtrationfiltered
5. 5
   Autredried

Mode opératoire

2.00 g (11.8 mmol) 4,5-difluoro-1,3-dihydro-indol-2-one I were stirred in 6.62 mL (55.0 mmol) acetic anhydride for 2 h at 150° C. The reaction mixture was added to ice water, the precipitated solid was suction filtered and washed with water. The product was recrystallised from a mixture of water and ethanol, suction filtered and dried.

Source