Réaction #161494

Équation de réaction

water

potassium carbonate

2-(methylthio)ethylamine

2-(4-fluoro-3-nitrophenyl)benzoxazole

→

title compound

Rendement 98.0%

N-(2-(methylthio)ethyl)-4-(benzoxazol-2-yl)-2-nitroaniline

Rendement 98.0%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Températurethis was heated
2. 2
   Températureto reflux for 3 hours
3. 3
   Filtrationafter the precipitated crystals were filtered
4. 4
   Lavagewashed with water, they
5. 5
   Autrewere dried

Mode opératoire

To a suspension of 2-(4-fluoro-3-nitrophenyl)benzoxazole (see Working Example 15-2) (300 mg, 1.16 mmol) in acetonitrile (5 mL) was added potassium carbonate (321 mg, 1.55 mmol) and 2-(methylthio)ethylamine (127 mg, 1.39 mmol), and this was heated to reflux for 3 hours. After the reaction was complete, this was cooled to room temperature, water was added, and after the precipitated crystals were filtered and washed with water, they were dried to yield the title compound (373 mg, 98% yield) as red crystals.

Source