Réaction #161247

Équation de réaction

4-bromobenzonitrile

nitric acid

→

4-bromo-3-nitrobenzonitrile

Rendement 56.0%

Solvants

H2SO4

Conditions de réaction

Traitement

1. 1
   workup.WAITat room temperature for 2.5 h
2. 2
   FiltrationThe white precipitate was collected via filtration
3. 3
   Lavagewashed with water until the washings
4. 4
   AutreThe solid was recrystallized from an ethanol/water mixture (1:1, 20 mL) twice

Mode opératoire

To a solution of 4-bromobenzonitrile (4.0 g, 22 mmol) in conc. H2SO4 (10 mL) was added dropwise at 0° C. nitric acid (6 mL). The reaction mixture was stirred at 0° C. for 30 min, and then at room temperature for 2.5 h. The resulting solution was poured into ice-water. The white precipitate was collected via filtration and washed with water until the washings were neutral. The solid was recrystallized from an ethanol/water mixture (1:1, 20 mL) twice to afford 4-bromo-3-nitrobenzonitrile as a white crystalline solid (2.8 g, 56%). 1H NMR (300 MHz, DMSO-d6) δ 8.54 (s, 1H), 8.06 (d, J=8.4 Hz, 1H), 7.99 (d, J=8.4 Hz, 1H); 13C NMR (75 MHz, DMSO-d6) δ 150.4, 137.4, 136.6, 129.6, 119.6, 117.0, 112.6; HPLC ret. time 1.96 min, 10-100% CH3CN, 5 min gradient; ESI-MS 227.1 m/z (MH+).

Source