Réaction #1605811

Équation de réaction

2-Phenylaniline

acetic anhydride

→

2-phenyl-N-acetylaniline

Rendement 99.5%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   ConcentrationThe solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONto the residue was added water (15 mL)
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature for 3 hours
4. 4
   FiltrationThe precipitate was collected by filtration
5. 5
   Lavagewashed with purified water
6. 6
   Autredried under reduced pressure

Mode opératoire

2-Phenylaniline (5 g, 29.55 mmol) was dissolved in acetic acid (30 mL), acetic anhydride (3.62 g, 35.45 mmol) was added thereto under ice bath, and the mixture was stirred under ice bath for 2 hours. The solution was concentrated under reduced pressure. to the residue was added water (15 mL), and the mixture was stirred at room temperature for 3 hours. The precipitate was collected by filtration, washed with purified water, and dried under reduced pressure to obtain 2-phenyl-N-acetylaniline (6.21 g).

Source