Réaction #1605805

Équation de réaction

4-(3-Amino-4-phenylphenyl)butyric acid

tosylic acid hydrate

water

→

benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate

Rendement 171.2%

Solvants

toluene

benzyl alcohol

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwere added
2. 2
   Températurethe mixture was heated
3. 3
   Autreremoved by a Dean-Stark trap
4. 4
   ConcentrationThe reaction solution was concentrated under reduced pressure
5. 5
   Autrea solid obtained
6. 6
   Lavagewas washed with a mixed solvent of hexane-ethyl acetate (4:1)
7. 7
   FiltrationThe solid was collected by filtration
8. 8
   Autredried under reduced pressure

Mode opératoire

To a suspension of 4-(3-Amino-4-phenylphenyl)butyric acid (21.6 g, 84.6 mmol) in toluene (300 mL), benzyl alcohol (50 mL) and tosylic acid hydrate (17.7 g, 93.0 mmol) were added, and the mixture was heated under reflux for 5 hours with water removed by a Dean-Stark trap. The reaction solution was concentrated under reduced pressure and a solid obtained was washed with a mixed solvent of hexane-ethyl acetate (4:1). The solid was collected by filtration and dried under reduced pressure to obtain benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate (41.2 g).

Source