Réaction #1605802

ord-61c1f225522147deb20973421acd404a

Équation de réaction

CN1CCC(OC(=O)Nc2cc(CCC(=O)OC(C)(C)C)ccc2-c2ccccc2)CC1
tert-butyl 3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate
Cl
hydrochloric acid
CN1CCC(OC(=O)Nc2cc(CCC(=O)O)ccc2-c2ccccc2)CC1.Cl
3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate hydrochloride

Solvants

Conditions de réaction

Température
70°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    ConcentrationThe reaction solution was concentrated under reduced pressure

Mode opératoire

To tert-butyl 3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate (5.08 g, 11.6 mmol) was added a 4M solution of hydrochloric acid in dioxane (70 mL) and the mixture was stirred at 70° C. for 2 hours. The reaction solution was concentrated under reduced pressure to obtain 3-[3-({[(1-methylpiperidin-4-yl)oxy]carbonyl}amino)-4-phenylphenyl]propionate hydrochloride (5.49 g).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US09072734B2uspto-grants-2015_07