Réaction #160263

ord-1a80b42781bd45dcb1885371b885eb67

Équation de réaction

FC(F)(F)c1cnc(Cl)c(Cl)c1
2,3-dichloro-5-(trifluoromethyl)pyridine
CCn1cc2cc(CNS(=O)(=O)c3ccc(C(=O)OC)cc3)ccc2n1
methyl 4-(N-((2-ethyl-2H-indazol-5-yl)methyl)sulfamoyl)benzoate
→
CCn1cc2cc(CN(c3ncc(C(F)(F)F)cc3Cl)S(=O)(=O)c3ccc(C(=O)OC)cc3)ccc2n1
titled compound
CCn1cc2cc(CN(c3ncc(C(F)(F)F)cc3Cl)S(=O)(=O)c3ccc(C(=O)OC)cc3)ccc2n1
Methyl 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((2-ethyl-2H-indazol-5-yl)methyl)sulfamoyl)benzoate

Réactifs

FC(F)(F)c1cnc(Cl)c(Cl)c1
2,3-dichloro-5-(trifluoromethyl)pyridine
CCn1cc2cc(CNS(=O)(=O)c3ccc(C(=O)OC)cc3)ccc2n1
methyl 4-(N-((2-ethyl-2H-indazol-5-yl)methyl)sulfamoyl)benzoate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The titled compound was prepared according to the procedure described in step-2 of Example 1 from 2,3-dichloro-5-(trifluoromethyl)pyridine and methyl 4-(N-((2-ethyl-2H-indazol-5-yl)methyl)sulfamoyl)benzoate (step-5 of Example 13).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08829026B2uspto-grants-2014_09