Réaction #1602

Équation de réaction

3-cyano-5-(4-chlorophenyl)-2-pyridinone

→

5-(4-chlorophenyl)-2-pyridinone

Rendement 75.6%

Solvants

H3PO4

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureat reflux for 16 hours
3. 3
   Filtrationfiltered

Mode opératoire

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

Source