Réaction #1596983

ord-7d203a1635b14679a3d1c9ca85f38d04

Équation de réaction

CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O

paclitaxel

carboplatin

paclitaxel

carboplatin

→

CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](N=C([O-])c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O.N.N.O=C([O-])C1(C(=O)O)CCC1.[Pt+2]

Carboplatin Paclitaxel

Réactifs

Réactifs

Aucun

Conditions de réaction

Conditions détaillées

See reaction.notes.procedure_details.

Traitement

1
Autrefor 12 days
2
workup.WAITon days 1, 4, 8 and 11 as set out in Table 10

Mode opératoire

Control mice received the saline vehicular control by interperitoneal (i.p.) injection every day for 12 days. A constant dose of SorC13 (300 mg/kg) was used throughout the experiments and injected i.p. every day for 12 days. Low (20 mg/kg carboplatin, 6 mg/kg paclitaxel), medium (40 mg carboplatin, 12 mg/kg paclitaxel) and high (60 mg/kg carboplatin, 24 mg/kg paclitaxel) doses of CAT were injected i.p. on days 1, 4, 8 and 11 as set out in Table 10.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08211857B2uspto-grants-2012_07