Réaction #1596952

Équation de réaction

1,2-dibromoethane

n-butyl lithium hexane

THF

dibenzofuran

→

Compound 16-1

Bromodibenzofuran

Solvants

Water

Conditions de réaction

Traitement

1. 1
   TempératureThe obtained solution is again cooled to −78° C.
2. 2
   Températurethe temperature of the solution is raised to room temperature over 120 minutes
3. 3
   Autrethe reaction
4. 4
   ExtractionOrganic layers extracted from the obtained mixture with ethyl acetate
5. 5
   Séchageare dried with sodium sulfate
6. 6
   Concentrationconcentrated with an evaporator

Mode opératoire

Under nitrogen current at −78° C., an n-butyl lithium hexane solution (1.6M, 69 ml) is dropped to a THF solution (175 ml) containing 16.82 g of dibenzofuran, and the temperature of the mixture is raised to room temperature over 80 minutes. The obtained solution is again cooled to −78° C., 19.0 ml of 1,2-dibromoethane is added to the solution, and the temperature of the solution is raised to room temperature over 120 minutes. Water is added to the obtained reaction solution to stop the reaction. Organic layers extracted from the obtained mixture with ethyl acetate are dried with sodium sulfate, and then concentrated with an evaporator to obtain 12.35 g of Compound 16-1.

Source