Réaction #159378

Équation de réaction

4-methyl-3-nitrophenol

butyl bromide

sodium carbonate

DMF

→

4-Butoxy-1-methyl-2-nitrobenzene

Solvants

MTBE

Conditions de réaction

Traitement

1. 1
   AutreThe cooled reaction solution
2. 2
   Lavagewashed twice each with water and sodium hydroxide solution
3. 3
   AutreThe organic phase was dried
4. 4
   Concentrationconcentrated
5. 5
   AutreThe product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way

Mode opératoire

A mixture of 4-methyl-3-nitrophenol (10.0 g), butyl bromide (9.4 g), sodium carbonate (6.9 g) and DMF (50 mL) was heated at 80° C. for 7 hours. The cooled reaction solution was diluted with MTBE and washed twice each with water and sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 209.25 (C11H15NO3) was obtained in this way; MS (ESI): 210 (M+H+).

Source