Réaction #158561

ord-49cb6853bfaa4fc7ab14e3ee828f54f4

Équation de réaction

Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine
Clc1ccnc(Cl)n1
2,4-dichloropyrimidine
Nc1cccc(O)c1
3-hydroxyaniline
Oc1cccc(Nc2ccnc(Nc3cccc(O)c3)n2)c1
N2,N4-bis(3-hydroxyphenyl)-2,4-pyrimidinediamine

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In a manner analogous to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloropyrimidine with 3-hydroxyaniline gave N2,N4-bis(3-hydroxyphenyl)-2,4-pyrimidinediamine. LCMS: ret. time: 16.21 min.; purity: 100%; MS (m/e): 295 (MH+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08822685B2uspto-grants-2014_09