Réaction #158498

ord-d6c57831b7c94c82a5d748219c5ddf42

Équation de réaction

Fc1cnc(Cl)nc1Cl
2,4-dichloro-5-fluoropyrimidine
CCOC(=O)C1CCN(Cc2cccc(N)c2)CC1
ethyl 1-(3-aminobenzyl)piperidine-4-carboxylate
→
CCOC(=O)C1CCN(Cc2cccc(Nc3nc(Cl)ncc3F)c2)CC1
2-chloro-N4-[3-[[4-(ethoxycarbonyl)piperidino]methyl]phenyl]-5-fluoro-4-pyrimidineamine

Réactifs

Fc1cnc(Cl)nc1Cl
2,4-dichloro-5-fluoropyrimidine
CCOC(=O)C1CCN(Cc2cccc(N)c2)CC1
ethyl 1-(3-aminobenzyl)piperidine-4-carboxylate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Autrewere reacted

Mode opératoire

In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and ethyl 1-(3-aminobenzyl)piperidine-4-carboxylate were reacted to provide 2-chloro-N4-[3-[[4-(ethoxycarbonyl)piperidino]methyl]phenyl]-5-fluoro-4-pyrimidineamine. LCMS: purity: 97%; MS (m/e): 394 (MH+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08822685B2uspto-grants-2014_09