Réaction #1583881

Équation de réaction

3-methylpyrrolidin-3-ol hydrochloride

3-methylpyrrolidin-3-ol hydrochloride

potassium carbonate

3-bromopropylbenzene

→

3-methyl-1-(3-phenylpropyl)pyrrolidin-3-ol

Rendement 70.4%

Solvants

acetonitrile

acetonitrile

Conditions de réaction

Traitement

1. 1
   Autrewas synthesized
2. 2
   AutreTo a 100 mL reaction flask
3. 3
   AutreAfter the completion of reaction
4. 4
   Autrethe resulting mixture was evaporated under reduced pressure
5. 5
   Autreto remove acetonitrile
6. 6
   workup.ADDITIONTo the residue was added a mixed solution of dichloromethane and water
7. 7
   Extractionfor extraction
8. 8
   SéchageThe organic phase was dried over anhydrous sodium sulfate
9. 9
   Autreevaporated
10. 10
    Autreto remove the solvent
11. 11
    Autreto produce a crude product
12. 12
    AutreThe crude product was purified by column chromatography (silica gel column, eluted with petroleum ether: ethyl acetate=10:1 (volumetric ratio))

Mode opératoire

According to Example 15, 3-methylpyrrolidin-3-ol hydrochloride was synthesized. To a 100 mL reaction flask were added 3-methylpyrrolidin-3-ol hydrochloride (1 g, 7.2 mmol), anhydrous potassium carbonate (2.5 g, 18 mmol) and acetonitrile (15 mL). To the resulting mixture was slowly added a solution of 3-bromopropylbenzene (1.29 g, 6.48 mmol) in acetonitrile dropwisely at 85° C. The reaction was conducted for 12 hours. After the completion of reaction monitored by TLC, the resulting mixture was evaporated under reduced pressure to remove acetonitrile. To the residue was added a mixed solution of dichloromethane and water for extraction. The organic phase was dried over anhydrous sodium sulfate, and evaporated to remove the solvent to produce a crude product. The crude product was purified by column chromatography (silica gel column, eluted with petroleum ether: ethyl acetate=10:1 (volumetric ratio)) to produce 3-methyl-1-(3-phenylpropyl)pyrrolidin-3-ol (1 g) in a yield of 70.4%.

Source