Réaction #1583879

Équation de réaction

2,2-diphenyl ethanol

triethylamine

MsCl

→

2,2-diphenylethyl methanesulfonate

Rendement 96.8%

Solvants

dichloromethane

—

three-opening

Conditions de réaction

Traitement

1. 1
   Autrewas conducted at 25° C
2. 2
   AutreAfter the completion of reaction
3. 3
   Lavagethe reaction solution was washed with water thrice
4. 4
   SéchageThe organic phase was dried over anhydrous sodium sulfate
5. 5
   Autreevaporated
6. 6
   Autreto remove the solvent

Mode opératoire

In a 500 mL three-opening flask, 2,2-diphenyl ethanol (17 g, 86 mmol) was dissolved in 170 mL dichloromethane. To the flask was added triethylamine (13.03 g, 129 mmol). The resulting mixture was stirred at 0° C. for half an hour. To the resulting mixture was slowly added MsCl (11.92 g, 104 mmol) dropwisely. The reaction was conducted at 25° C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23 g) in a yield of 96.78%.

Source