Réaction #1583868

Équation de réaction

Thionyl chloride

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

→

crude product

methyl 5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONAfter the completion of the dropwise addition
2. 2
   Températureunder cooling in an ice bath until the solution
3. 3
   AutreAfter the completion of reaction
4. 4
   Autrethe reaction solution was rotary evaporated to dryness

Mode opératoire

Thionyl chloride (0.4 g, 3.4 mmol) was slowly added to a solution of 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (1.0 g, 3 mmol) in dichloromethane dropwisely at −25° C. After the completion of the dropwise addition, the reaction was continued under cooling in an ice bath until the solution became clear. After the completion of reaction, the reaction solution was rotary evaporated to dryness to produce a crude product, which was directly used in the next step.

Source