Réaction #158015

ord-d1e57d16ae2146cebccf0bfb4c8aaff0

Équation de réaction

CC(C)(C)OC(=O)CC(Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C
tert-butyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate
Cl
HCl
C1COCCO1
1,4-dioxane
→
CC(C)(C)OC(=O)CC(N)Cc1ccc(-c2ccccc2)cc1.Cl
3-amino-4-biphenyl-4-yl-butyric acid tert-butyl ester hydrochloride

Réactifs

CC(C)(C)OC(=O)CC(Cc1ccc(-c2ccccc2)cc1)NC(=O)OC(C)(C)C
tert-butyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate
Cl
HCl
C1COCCO1
1,4-dioxane

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    Concentrationthe reaction mixture is concentrated

Mode opératoire

To tert-butyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate (110 mg, 0.267 mmol), a solution of 4 M HCl in 1,4-dioxane (0.668 ml, 2.67 mmol) is added. After stirring for 1 h, the reaction mixture is concentrated to give crude 3-amino-4-biphenyl-4-yl-butyric acid tert-butyl ester hydrochloride.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08822534B2uspto-grants-2014_09