Réaction #157788

Équation de réaction

[4-(cyclopropylsulfanyl)phenyl](6-methoxy-5-methylpyridin-2-yl)methanone

5-({[1-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopropyl]methyl}sulfonyl)-1-phenyl-1H-tetrazole

→

1-phenyl-5-[(tetrahydrofuran-3-ylmethyl)sulfonyl]-1H-tetrazole

Conditions de réaction

Traitement

1. 1
   Autrethe same reaction as in Examples 1-47(1), 1-2 and 1-1(2) sequentially except
2. 2
   Autreobtained in Reference Example 1-37

Mode opératoire

The title compound was obtained as a pale yellow solid (3.2 mg, 1% (three steps)) by performing substantially the same reaction as in Examples 1-47(1), 1-2 and 1-1(2) sequentially except for using [4-(cyclopropylsulfanyl)phenyl](6-methoxy-5-methylpyridin-2-yl)methanone obtained in Reference Example 1-37 and using 5-({[1-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopropyl]methyl}sulfonyl)-1-phenyl-1H-tetrazole obtained in Reference Example 3-13 in place of 1-phenyl-5-[(tetrahydrofuran-3-ylmethyl)sulfonyl]-1H-tetrazole.

Source