Réaction #157287

Équation de réaction

methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate

methylhydrazine

→

product

Rendement 80.3%

2-(5-hydroxy-1-methyl-1H-pyrazol-3-ylmethyl)-isoindol-1,3-dione

Rendement 80.3%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   TempératureThe reaction mixture is cooled
2. 2
   Filtrationsuction filtered
3. 3
   Lavagewashed with ethanol

Mode opératoire

10.0 g methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate are dissolved at 60° C. in 200 ml of ethanol and 1.94 g methylhydrazine are added. The reaction mixture is cooled and stirred further at ambient temperature. After 5 hours the precipitated substance is suction filtered and washed with ethanol. 7.91 g of the product are obtained as a powder.

Source