Réaction #1572832

Équation de réaction

tert-butyl 4-((4-((4-hydroxybenzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate

3-chloro-2-(chloromethyl)prop-1-ene

K2CO3

→

tert-butyl 4-(4-(4-(2-(chloromethyl)allyloxy)benzylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate

Rendement 36.7%

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureto reflux for 16 hours
3. 3
   AutreThe solvent was removed under vacuum
4. 4
   AutreThe residue was purified by silica gel column (hexanes:EtOAc=10:1 to 4:1)

Mode opératoire

A suspension of tert-butyl 4-((4-((4-hydroxybenzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate (3 g), 3-chloro-2-(chloromethyl)prop-1-ene (1.15 g) and K2CO3 (1.69 g) in acetone (20 mL) was heated to reflux for 16 hours. The solvent was removed under vacuum. The residue was purified by silica gel column (hexanes:EtOAc=10:1 to 4:1) to give tert-butyl 4-(4-(4-(2-(chloromethyl)allyloxy)benzylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzoate (1.3 g).

Source