Réaction #157088

Équation de réaction

TFA

1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

→

3-methylpiperidine-3-carboxylic acid

Solvants

CH2Cl2

Conditions de réaction

Traitement

1. 1
   Concentrationwas concentrated in vacuo
2. 2
   Autreazeotroped once with toluene

Mode opératoire

TFA was added to a solution of 1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid (1 eq) in CH2Cl2 (0.5 M). After stirring for 3 h at it the reaction mixture was concentrated in vacuo and azeotroped once with toluene to give 3-methylpiperidine-3-carboxylic acid (TFA salt). The crude product was used for the next step without further purification.

Source