Réaction #156752

Équation de réaction

(1R,3S)-3-aminocyclopentanecarboxylic acid

methanol

thionyl chloride

→

title compound

(1R,3S)-Methyl 3-aminocyclopentanecarboxylate hydrochloride

Conditions de réaction

Traitement

1. 1
   Températureto warm to room temperature
2. 2
   workup.STIRRINGstirred overnight
3. 3
   AutreThe resulting clear solution was evaporated
4. 4
   Autreazeotroped with methanol (2×5 mL)
5. 5
   Autreair-dried

Mode opératoire

A suspension of (1R,3S)-3-aminocyclopentanecarboxylic acid (500 mg, 3.8 mmol) in methanol (10 mL) was stirred at 0° C. and thionyl chloride (1.40 mL, 19.3 mmol) was added dropwise. The mixture was allowed to warm to room temperature and stirred overnight. The resulting clear solution was evaporated, azeotroped with methanol (2×5 mL), air-dried and the title compound obtained as a white powder (680 mg).

Source