Réaction #156650

ord-66cab9aaff244343ad74e592e47d8a41

Équation de réaction

COCC(C)N1CCCN(c2ccc(N3CCc4cc(O)ccc4C3=O)cc2OC)CC1
6-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-one
CS(=O)(=O)C[C@H]1CCCO1
(R)-2-methanesulfonylmethyl-tetrahydrofuran
→
COCC(C)N1CCCN(c2ccc(N3CCc4cc(OC[C@H]5CCCO5)ccc4C3=O)cc2OC)CC1
2-{3-Methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-6-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

Réactifs

COCC(C)N1CCCN(c2ccc(N3CCc4cc(O)ccc4C3=O)cc2OC)CC1
6-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-one
CS(=O)(=O)C[C@H]1CCCO1
(R)-2-methanesulfonylmethyl-tetrahydrofuran

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreIn this way the product was obtained with molecular weight 523.68 (C30H41N3O5)

Mode opératoire

6-Hydroxy-2-{3-methoxy-4-[4-(2-methoxy-1-methyl-ethyl)-[1,4]diazepan-1-yl]-phenyl}-3,4-dihydro-2H-isoquinolin-1-one and (R)-2-methanesulfonylmethyl-tetrahydrofuran were reacted according to Method K1. In this way the product was obtained with molecular weight 523.68 (C30H41N3O5); MS (ESI): 524 (M+H+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08822495B2uspto-grants-2014_09