Réaction #156600

ord-6a826a81dcd2417bb000a370cbee0968

Équation de réaction

CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC(=O)C3)cc1)C2=O
6-Butoxy-2-[4-(3-oxopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
CC(=O)N1CCNCC1
1-piperazin-1-ylethanone
→
CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC(N4CCN(C(C)=O)CC4)C3)cc1)C2=O
2-{4-[3-(4-Acetylpiperazin-1-yl)pyrrolidin-1-yl]phenyl}-6-butoxy-3,4-dihydro-2H-isoquinolin-1-one

Réactifs

CCCCOc1ccc2c(c1)CCN(c1ccc(N3CCC(=O)C3)cc1)C2=O
6-Butoxy-2-[4-(3-oxopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one
CC(=O)N1CCNCC1
1-piperazin-1-ylethanone

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThe product with the molecular weight of 490.65 (C29H38N4O3) was obtained in this way

Mode opératoire

6-Butoxy-2-[4-(3-oxopyrrolidin-1-yl)phenyl]-3,4-dihydro-2H-isoquinolin-1-one was reacted with 1-piperazin-1-ylethanone by method J. The product with the molecular weight of 490.65 (C29H38N4O3) was obtained in this way; MS (ESI): 491 (M+H+).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08822495B2uspto-grants-2014_09