Réaction #1563907

Équation de réaction

NaHCO3

3,4-(Methylenedioxy)aniline

Ac2O

→

N-(benzo[d][1,3]dioxol-5-yl)acetamide

Rendement 95.0%

Solvants

AcOH

Conditions de réaction

Traitement

1. 1
   AutreAfter reaction
2. 2
   Filtrationfiltered
3. 3
   ExtractionThe filtrate was extracted with ethyl acetate

Mode opératoire

To a solution of 3,4-(Methylenedioxy)aniline (8 g, 58.3 mmol) in AcOH (120 ml) was added Ac2O (48 mL). The mixture was stirred for overnight. After reaction, the mixture was poured into saturated NaHCO3 solution, and then filtered. The filtrate was extracted with ethyl acetate to give N-(benzo[d][1,3]dioxol-5-yl)acetamide (10 g, 95%). LCMS: 180[M+1]+; 1H NMR (DMSO-d6) δ 2.0 (s, 3H), 5.96 (s, 2H), 6.82 (d, 1H, J=8.1 Hz), 6.91 (d, 1H, J=2.1 Hz), 7.30 (d, 1H, J=1.8 Hz), 9.84 (s, 1H).

Source