Réaction #1563891

Équation de réaction

bis(2-bromoethyl)amine

Compound 25

2-amino-N-(2-methoxyphenyl)-6-(4-nitrophenylthi-o)benzamide

NaOH

→

solid

Rendement 82.0%

N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)-6-(piperazinyl)benzamide

Rendement 82.0%

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Autreto get crude product
2. 2
   FiltrationThe crude solid was filtered
3. 3
   Lavagewashed several times with water
4. 4
   Autrepurified by silica gel column chromatography (1:3 v/v ethyl acetate/petroleum ether)

Mode opératoire

Compound 25 (1.0 equiv.) was dissolved in DMF (40 mL) at room temperature. To this mixture bis(2-bromoethyl)amine (1.0 equiv.) was added, following the addition of NaOH (2.0 equiv.). After being stirred for 2 Hours at room temperature, the reaction mixture was poured into ice-cold water (200 mL) to get crude product. The crude solid was filtered and washed several times with water and purified by silica gel column chromatography (1:3 v/v ethyl acetate/petroleum ether) to provide a yellow solid (380.9 mg, 82% yield).

Source