Réaction #1563885
ord-2179c3480452424381165a3a1df2e059
Équation de réaction
4-(4-chlorophenyl)-1H-imidazole
2-bromothiophene
→
4-(4-chlorophenyl)-1-(thiophen-2-yl)-1H-imidazole
Rendement 7.0%
Réactifs
Aucun
Conditions de réaction
Conditions détaillées
See reaction.notes.procedure_details.
Mode opératoire
The procedure described above in Example 29 for Formula IIc-iii was followed, starting from 4-(4-chlorophenyl)-1H-imidazole (125 mg, 0.595 mmol) and 2-bromothiophene, to prepare the desired 4-(4-chlorophenyl)-1-(thiophen-2-yl)-1H-imidazole (11 mg, 0.042 mmol, yield 7.0%) as a reddish sticky solid. The HPLC purity of the final product was 95.62%. LC-MS [M+H] 261 (C13H9ClN2S+1 expected 261.02). The 1H-NMR spectra was in accordance with the chemical structure.