Réaction #156052

ord-f9f76531b0fd4ddbbe2219102168db42

Équation de réaction

Cl.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1
N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride
CCCOc1cnc(Cl)nc1
2-chloro-5-propoxy-pyrimidine
→
CCCOc1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)nc1
N-Cyclopropyl-4-oxazol-5-yl-N-[1-(5-propoxy-pyrimidin-2-yl)-piperidin-4-yl]-benzamide
CCCOc1cnc(N2CCC(N(C(=O)c3ccc(-c4cnco4)cc3)C3CC3)CC2)nc1
title compound

Réactifs

Cl.O=C(c1ccc(-c2cnco2)cc1)N(C1CCNCC1)C1CC1
N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride
CCCOc1cnc(Cl)nc1
2-chloro-5-propoxy-pyrimidine

Réactifs

Aucun

Solvants

CN1CCCC1=O
N-methylpyrrolidinone

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2-chloro-5-propoxy-pyrimidine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.49 min; Mass spectrum (ESI+): m/z=448 [M+H]+.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08822471B2uspto-grants-2014_09