Réaction #155774

Équation de réaction

TFA DCM

t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate

→

2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetic acid

Rendement 82.0%

Conditions de réaction

Traitement

1. 1
   AutreThe organic solvent was removed in vacuo
2. 2
   Autrethe crude product was purified by reversed phase preparative HPLC

Mode opératoire

To a solution of TFA/DCM (1:3, 6 mL) was added t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetate (8) (51 mg, 0.10 mmol, 1 eq) and the mixture was stirred at room temperature for 2 h. The organic solvent was removed in vacuo and the crude product was purified by reversed phase preparative HPLC to give 36 mg (82%) of 2-(2-(3-cyanophenyl)-4-((4-fluorophenylsulfonamido)methyl)phenoxy)acetic acid (Example 9).

Source