Réaction #155439

Équation de réaction

sodium borohydride

2-cyclopentylaminoindanone

→

trans-2-cyclopentylamino-1-hydroxyindane

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONis added over a period of about 1 hour
2. 2
   FiltrationAfter filtration with suction
3. 3
   Autredrying in air, it
4. 4
   workup.STIRRINGis stirred with n-heptane

Mode opératoire

0.5 g of sodium borohydride, divided into 4 portions, is added over a period of about 1 hour while stirring to the 2-cyclopentylaminoindanone obtained in step 1 in aqueous solution of pH 3 (about 20 ml). After further stirring at room temperature for about 3-4 hours, a white precipitate separates out. After filtration with suction and drying in air, it is stirred with n-heptane. 320 mg of trans-2-cyclopentylamino-1-hydroxyindane are obtained.

Source