Réaction #155369

Équation de réaction

1c

3-({3-[2-(4-Cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-phenyl-amino)-propionic acid methyl ester

→

crude product

Rendement 58.0%

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid methyl ester

Rendement 58.0%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températureto reflux for one hour
2. 2
   AutreThe solution was then evaporated to dryness
3. 3
   Autrethe remaining solid triturated with water

Mode opératoire

A solution of the product of 1c (22.6 mmol) in 100 mL concentrated acetic acid was heated to reflux for one hour. The solution was then evaporated to dryness, the remaining solid triturated with water and under stirring the pH was adjusted to about 8-9. The crude product was isolated through extraction with ethyl acetate and purified by chromatography on silica gel (eluent: dichloromethane/ethanol 1:1).

Source