Réaction #155367

ord-58567c32622f4b2a9ffc9a6fe55bc69b

Équation de réaction

CNc1ccc(C(=O)N(CCC(=O)OC)c2ccccc2)cc1[N+](=O)[O-]
product 1a
CNc1ccc(C(=O)N(CCC(=O)OC)c2ccccc2)cc1[N+](=O)[O-]
3-[(4-Methylamino-3-nitro-benzoyl)-phenyl-amino]-propionic acid methyl ester
→
CNc1ccc(C(=O)N(CCC(=O)OC)c2ccccc2)cc1N
3-[(3-Amino-4-methylamino-benzoyl)-phenyl-amino]-propionic acid methyl ester

Réactifs

CNc1ccc(C(=O)N(CCC(=O)OC)c2ccccc2)cc1[N+](=O)[O-]
product 1a
CNc1ccc(C(=O)N(CCC(=O)OC)c2ccccc2)cc1[N+](=O)[O-]
3-[(4-Methylamino-3-nitro-benzoyl)-phenyl-amino]-propionic acid methyl ester

Réactifs

[Pd]
Pd

Solvants

CCO
ethanol

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The nitro group of product 1a was reduced by hydrogenation at room temperature in ethanol with Pd (10% on charcoal) as catalyst.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08821871B2uspto-grants-2014_09