Réaction #155357

ord-7ab8edc9b30140f7a9f521ad576d3f85

Équation de réaction

N[C@@H](CCC(=O)O)C(=O)[O-].[Na+]
monosodium glutamate
N[C@@H](CC(=O)O)C(=O)[O-].[Na+]
monosodium aspartate
[Al+3].[OH-].[OH-].[OH-]
aluminium hydroxide
→
N[C@@H](CC(=O)O)C(=O)[O-].N[C@@H](CCC(=O)O)C(=O)[O-].[Na+].[Na+]
MSG MSA

Réactifs

N[C@@H](CCC(=O)O)C(=O)[O-].[Na+]
monosodium glutamate
N[C@@H](CC(=O)O)C(=O)[O-].[Na+]
monosodium aspartate
[Al+3].[OH-].[OH-].[OH-]
aluminium hydroxide

Réactifs

Aucun

Solvants

O
water

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

A solution of 50% by weight (total) of a mixture of monosodium glutamate (MSG) and monosodium aspartate (MSA) in equal molar ratio, is prepared in water and an active biological agent (in this example hepatitis B/aluminium hydroxide adjuvanted vaccine) added in a quantity to give a final MSG/MSA to adjuvant ratio of 40:1.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08821437B2uspto-grants-2014_09