Réaction #155319

Équation de réaction

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

Rendement 87.6%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autrefollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   AutreThe catalyst was removed by celite filtration
3. 3
   Autrecondensed under reduced pressure
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated to dryness under reduced pressure

Mode opératoire

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

Source