Réaction #1552137

Équation de réaction

tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate

HCl EtOAc

→

title compound

4-cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

Solvants

EtOAc

Conditions de réaction

Traitement

1. 1
   Autrethe solvent was removed in vacuo
2. 2
   Filtrationthe white precipitate was collected by filtration

Mode opératoire

A mixture of tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate (687 mg, 2.06 mmol) and 4 M HCl-EtOAc (30 ml) were stirred at rt for 2 h. Then EtOAc was added, and the solvent was removed in vacuo. The residue was suspended in EtOAc, and the white precipitate was collected by filtration to give 525 mg (quant) of the title compound as a white solid. The compound was used for the next step without further purification.

Source