Réaction #1552095

Équation de réaction

3-(3,3-dimethylbut-1-yn-1-yl)aniline

hydrogen

→

3-(3,3-dimethylbutyl)cyclohexanamine

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   Filtrationthe catalyst is filtered off through kieselguhr
2. 2
   Concentrationthe product is concentrated under reduced pressure

Mode opératoire

0.5 g of Ru/C 5% is added to a solution consisting of 1.04 g (0.6 mol) of 3-(3,3-dimethylbut-1-yn-1-yl)aniline in 20 ml of tetrahydrofuran, and the mixture is hydrogenated with 100 bar of hydrogen at 120° C. for 40 hours. After cooling to room temperature, the catalyst is filtered off through kieselguhr and the product is concentrated under reduced pressure. This gives 0.9 g (81% of theory) of 3-(3,3-dimethylbutyl)cyclohexanamine as main component according to MSD-HPLC.

Source