Réaction #1552084

Équation de réaction

methyl 4-(4-butylphenyl)benzoate

NaOH

→

4-(4-butylphenyl)benzoic acid

Rendement 71.1%

Solvants

THF H2O

Conditions de réaction

Traitement

1. 1
   Températurewas heated
2. 2
   Températureto reflux overnight
3. 3
   AutreTHF was removed
4. 4
   FiltrationThe resulting mixture was filtered
5. 5
   Lavagethe cake was washed with water
6. 6
   Autredried

Mode opératoire

A mixture of methyl 4-(4-butylphenyl)benzoate (89.0 g, 0.332 mol), NaOH (26.6 g, 0.664 mol) in THF/H2O (500 mL/100 mL) was heated to reflux overnight. After TLC showed the reaction was complete, THF was removed. The residue was adjusted pH ˜3-4 with 2 N HCl solution. The resulting mixture was filtered and the cake was washed with water, dried to give 4-(4-butylphenyl)benzoic acid (60.0 g, yield: 71.1%), as a white solid. (ESI) m/z 255.0 (M+H)+.

Source