Réaction #1552056

Équation de réaction

5-allyloxy-2-nitrobenzyl alcohol

m-chloroperoxybenzoic acid

→

5-glycidyloxy-2-nitrobenzyl alcohol

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autrepeaks disappeared from the 1H-NMR spectrum (approximately 48 hours)
2. 2
   LavageThe reaction was then washed with aqueous sodium carbonate twice
3. 3
   Séchagewater three times and then dried over sodium sulfate
4. 4
   AutreThe solvent was partially removed by rotary evaporation
5. 5
   workup.ADDITIONpoured into hexanes
6. 6
   Autreto precipitate the product
7. 7
   FiltrationThe resulting solid was collected by suction filtration
8. 8
   Autrewas used in the next step without further purification

Mode opératoire

5-allyloxy-2-nitrobenzyl alcohol (7.3 g, 35 mmol) and m-chloroperoxybenzoic acid (77 wt. %, 9.4 g, 42 mmol) were dissolved in dichloromethane and refluxed until the allyl peaks disappeared from the 1H-NMR spectrum (approximately 48 hours). The reaction was then washed with aqueous sodium carbonate twice, water three times and then dried over sodium sulfate. The solvent was partially removed by rotary evaporation and then poured into hexanes to precipitate the product. The resulting solid was collected by suction filtration and was used in the next step without further purification.

Source