Réaction #1552037

Équation de réaction

palmitoyl chloride

N-hydroxysuccinimide

triethylamine

→

N-palmitoyloxy-Succinimide

Solvants

chloroform

Conditions de réaction

Traitement

1. 1
   LavageAfter washed with 500 mL of water three times
2. 2
   Séchagethe resultant solution was dried over magnesium sulfate
3. 3
   Concentrationwas then concentrated under reduced pressure
4. 4
   Autreto obtain 260.3 g (quant) of a colorless solid

Mode opératoire

To a solution of 165 mL (0.544 mol) of palmitoyl chloride in 1 L of chloroform while cooled with ice with stirring, 69.8 g (0.598 mol) of N-hydroxysuccinimide was gradually added, and 83.1 mL (0.598 mol) of triethylamine was added dropwise thereto over 30 minutes. The resultant solution was stirred for 30 minutes while cooled with ice and for another 7 hours during which the resultant solution gradually reached room temperature. After washed with 500 mL of water three times, the resultant solution was dried over magnesium sulfate and was then concentrated under reduced pressure to obtain 260.3 g (quant) of a colorless solid.

Source