Réaction #1536359

Équation de réaction

2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine

phenylacetyl chloride

→

4-amino-2-phenylacetamido-5-(3,4,5-trimethoxybenzyl)-pyrimidine

Solvants

chlorobenzene

Conditions de réaction

Traitement

1. 1
   AutreAt 125° C.
2. 2
   Températureis maintained at this temperature for five hours
3. 3
   FiltrationThe difficultly soluble trimethoprim hydrochloride is filtered off
4. 4
   Concentrationthe filtrate is concentrated in vacuo
5. 5
   AutreUpon recrystallization from ethanol

Mode opératoire

5.8 g of 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (trimethoprim) are suspended in 58 ml of chlorobenzene. At 125° C., 1.55 g of phenylacetyl chloride are dripped in, and the whole is maintained at this temperature for five hours. The difficultly soluble trimethoprim hydrochloride is filtered off and the filtrate is concentrated in vacuo. Upon recrystallization from ethanol there is obtained 4-amino-2-phenylacetamido-5-(3,4,5-trimethoxybenzyl)-pyrimidine of melting point 181° to 183° C.

Source