Réaction #1519111

Équation de réaction

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate

N-Chlorosuccinimide

water

→

title intermediate

Ethyl 2-(2-Formylamino-5-chlorothiazol-4-yl)-2-oxoacetate

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   FiltrationThe resulting white precipitate was filtered
2. 2
   Lavagewashed with water and air
3. 3
   Autredried

Mode opératoire

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.

Source