Réaction #1519094

Équation de réaction

4-Benzyloxybenzyl chloride

triphenyl phosphine

ether

→

4-benzyloxybenzyltriphenyl phosphonium chloride

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   FiltrationThe precipitated phosphonium salt was collected by filtration
2. 2
   Lavagerinsed with ether and air
3. 3
   Autredried

Mode opératoire

4-Benzyloxybenzyl chloride (1 g, 0.0043 moles) and triphenyl phosphine (1.127 g, 1 equivalent) in anhydrous toluene (20 mL) were refluxed under nitrogen for ˜8-10 hours. A white precipitate appeared in the reaction mixture. The reaction mixture was then cooled to room temperature and ether (100 mL) was added. The precipitated phosphonium salt was collected by filtration, rinsed with ether and air dried. Yield=0.55 g (25%). MALDI-TOF MS 459.51 obs. (459.54 calc.).

Source